Miracles and Mistakes: From Penicillin through Antimicrobial Resistance to Paxlovid

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de Jager Auditorium

With Professor Chris Butler

This talk tells an Oxford story, from the discovery and development of penicillin to the modern clinical evaluation of treatments for COVID-19 and other common viral infections. It explores how one of medicine’s great miracles also led to one of its great mistakes: the overuse of antimicrobials and the rise of resistance. Drawing on recent Oxford-led community-based clinical trials, Chris will argue that we must not repeat the same error with the new treatments for viral infections now coming to market at pace. Rapid, inclusive and rigorous clinical trials are essential to ensure that new treatments are used wisely — for the right people, at the right time, and for the greatest benefit to society. In doing so, they may help humanity avoid the next great infectious disease catastrophe.