Lecturer in Medicine

Chris Horton

  • I am Lecturer in Geriatric Medicine at the Oxford Medical School.

  • I am Academic Foundation Doctor at Oxford University Hospitals NHS Trust with special interest in immunological mechanisms in transplant surgery.

  • I graduated from Oxford University with BM BCh in 2019, completing my preclinical years at Trinity.

A detail from the back gate to Trinity College, with a gryphon in metal.

Teaching

Outside my time on the wards, I thoroughly enjoy engaging in teaching at all levels across the medical course. Currently, I provide Organisation of the Body tutorials to first-year medical students at Trinity, covering topics in gross human anatomy and embryology. As a Fellow in Anatomy, I provide demonstration room seminars to first- and third-year medical students and have recently produced three textbooks entitled The Principles of Clinical Anatomy with Mr Tom Cosker and Professor John Morris, for the use of Oxford medical students.

On the clinical course, I regularly provide lectures in geriatric medicine and bedside teaching to fifth-year medical students. In partnership with the course organisers, I am currently working to modernise the geriatric medicine course, by integrating online teaching platforms with traditional, lecture and ward-based teaching.

Research

I completed my BM BCh degree last year, having completed my pre-clinical years and undergraduate degree in Medical Sciences at Trinity. I now work as an Academic Foundation Doctor in the John Radcliffe Hospital, Oxford, which allows me to continue to be actively engaged in research whilst training as a junior doctor.

For much of my time in Oxford, initially as a medical student, and now as a junior doctor, I have been actively involved in both basic science and clinical research. I have recently carried out projects with interventional radiologists, orthopaedic surgeons and spinal surgeons, and have presented my work at National Conferences. During my undergraduate studies at Trinity College, I worked under Professor Paul Fairchild, at the Sir William Dunn School of Pathology, developing novel methods to generate immunogenic and tolerogenic dendritic cells from induced pluripotent stem cells. This work has allowed us to create a theoretically infinite supply of functional, adult-phenotype antigen presenting cells, which can be used in cancer immunotherapy and transplant tolerance research.

Selected Publications

Carroll, L., Braeutigam, S., Dawes, J., Krsnik, Z., Kostovic, I., Coutinho, E., Dewing, J., Horton, C., Gomez-Nicola, D. and Menassa, D, ‘Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity’, The Neuroscientist 2020 (ePub ahead of print)

Whiles, E., Shafafy, R., Valsamis, E., Horton, C., Morassi, G., Stokes, O. & Elsayed, S., ‘The Management of Symptomatic Lumbar Disc Herniation in Pregnancy: A Systematic Review’, Global Spine Journal December 2019 (ePub ahead of print)

Horton, C., Davies, T., Lahiri, P., Sachamitr, P. & Fairchild, P., ‘iPS cells reprogrammed from primary dendritic cells provide an abundant source of immunostimulatory dendritic cells for use in immunotherapy’, Stem Cells 2019 38, 67-79

Fairchild, P., Davies, T., Horton, C., Shanmugarajah, K. & Bravo, M., ‘Immunotherapy with iPSC-derived dendritic cells brings a new perspective to an old debate: autologous versus allogeneic?’, Cell & Gene Therapy Insights 2019; 5(5), 565–566.

Horton C, Shanmugarajah K, Fairchild PJ., ‘Harnessing the properties of dendritic cells in the pursuit of immunological tolerance’, Biomedical Journal 2017 40, 80–93

Fairchild, P., Horton, C., Lahiri, P., Shanmugarajah, K. & Davies, T., ‘Beneath the sword of Damocles: regenerative medicine and the shadow of immunogenicity’, Regenerative Medicine 11 (2016), 817-829