Adrian Kendal

At Trinity, I provide tutorial support on the ‘Organsiation of the Body’ paper for first-year undergraduate students studying the First BM Part 1.

My research aim is to understand the pathogenesis of chronic debilitating tendon disease. Tendon disease accounts for over 30% of primary care consultations and represents a growing healthcare challenge in an active and increasingly ageing population. Recognising critical cells involved in tendinopathy is essential in developing therapeutics to meet this challenge.

We apply combined single cell transcriptomics and surface proteomics to identify novel tendon cell sub-types in diseased and healthy human tendon.

For the first time, we have shown that human tendon harbours at least five distinct COL1A1/2 expressing tenocyte populations in addition to endothelial cells, T-cells, and monocytes. We are interested in the temporal-spatial interaction of particular tendon cell sub-types in the pathogenesis of chronic tendinopathy, for example we observe increased expression of pro-inflammatory markers PTX3, CXCL1, CXCL6, CXCL8, and PDPN by microfibril gene associated tenocytes.

Kendal A.R., Layton T., Al-Mossawi H., Dakin S., Sharp R., Brown R., Rogers M., Loizou C., Carr A., ‘Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendon’, Scientific Reports (2020) (in press)

Kendal A.R., Layton T., Al-Mossawi H., Dakin S., Sharp R., Brown R., Rogers M., Loizou C., Carr A., ‘Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomics’, BioRxiv (2019)

Kendal, A., Snelling, S., Dakin, S., Stace, E., Mouthuy, P-A., Carr, A., ‘Resorbable electrospun polydioxanone fibres modify the behaviour of cells from both health and diseased human tendons’, Eur cell mater (2017) 33, 169-182

‘Conversion rate of isolated talo-calcaneal (subtalar) arthrodesis to triple fusion; five year study’, Foot and ankle surgery (2016)

Hilbrands, R., Chen, Y., Kendal, A.R., Adams, E., Cobbold, S.P., Waldemann, H., Howie, D., ‘Induced Foxp3(+) T Cells Colonizing Tolerated Allografts Exhibit the Hypomethylation Pattern Typical of Mature Regulatory T Cells’, Front immunol (2016) 7

Kendal, A.R., Khalid, A., Ball, T., Rogers, M., Cooke, P., Sharp, P., ‘Complications of minimally invasive calcaneal osteotomy versus open osteotomy’, Foot & ankle international (2015) 36, 685-690

Kendal, A.R., Cooke, P., Sharp, R., ‘Arthroscopic Ankle Fusion for Avascular Necrosis of the Talus’, Foot & ankle international (2015) 36, 591-597

Kendal, A.R., Prieto-Alhambra, D., Arden, N.K., Carr, A., Judge, A., ‘Mortality rates at 10 years after metal-on-metal hip resurfacing compared with total hip replacement in England: retrospective cohort analysis of hospital episode statistics’, BMJ (2013) 347