Adrian Kendal

At Trinity, I provide tutorial support on the ‘Organsiation of the Body’ paper for first-year undergraduate students studying the First BM Part 1.

My research aim is to understand the pathogenesis of chronic debilitating tendon disease. Tendon disease accounts for over 30% of primary care consultations and represents a growing healthcare challenge in an active and increasingly ageing population. Recognising critical cells involved in tendinopathy is essential in developing therapeutics to meet this challenge.

We apply combined single cell transcriptomics and surface proteomics to identify novel tendon cell sub-types in diseased and healthy human tendon.

For the first time, we have shown that human tendon harbours at least five distinct COL1A1/2 expressing tenocyte populations in addition to endothelial cells, T-cells, and monocytes. We are interested in the temporal-spatial interaction of particular tendon cell sub-types in the pathogenesis of chronic tendinopathy, for example we observe increased expression of pro-inflammatory markers PTX3, CXCL1, CXCL6, CXCL8, and PDPN by microfibril gene associated tenocytes.

Hennessy, C., et al., Mortality and Re-Amputation Rates Following Below Knee Amputation: A Systematic Review and Meta-Analysis. British Journal of Surgery, 2024. 111.

Woods, A., et al., Association of Preexisting Triple Fusion and Arthroscopic Ankle Arthrodesis nonunion. Foot & Ankle International, 2023. 44(7): p. 579-586.

Cherief, M., et al., TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair. Science Translational Medicine, 2023. 15(727).

Sharma, A., et al., The Application and Patient-Reported Experience of Telephone Consultations in Elective Foot and Ankle Orthopaedic Surgery: 12-Month Follow-up. Foot & Ankle International, 2022. 43(5): p. 694-702.

Gomez-Collignon, A., et al., SINGLE-CELL MULTI-OMICS CHARACTERISE DISCRETE HUMAN TENDON CELLS POPULATIONS THAT PERSIST <i>IN VITRO</i> AND ON FIBROUS SCAFFOLDS. European Cells & Materials, 2022. 44: p. 1-20.

Kendal, A.R., et al., Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendon. Scientific Reports, 2020. 10(1).

Kendal, A., et al., RESORBABLE ELECTROSPUN POLYDIOXANONE FIBRES MODIFY THE BEHAVIOUR OF CELLS FROM BOTH HEALTHY AND DISEASED HUMAN TENDONS. European Cells & Materials, 2017. 33: p. 169-182.

Kendal, A.R., et al., Mortality rates at 10 years after metal-on-metal hip resurfacing compared with total hip replacement in England. British Journal of Sports Medicine, 2016. 50(3): p. 187-187.

Hilbrands, R., et al., Induced Foxp3<SUP>+</SUP> T Cells Colonizing Tolerated Allografts Exhibit the Hypomethylation Pattern Typical of Mature Regulatory T Cells. Frontiers in Immunology, 2016. 7.

Foulke, B.A., et al., Fracture healing in the elderly: A review. Maturitas, 2016. 92: p. 49-55.

Kendal, A.R., et al., Complications of Minimally Invasive Calcaneal Osteotomy Versus Open Osteotomy. Foot & Ankle International, 2015. 36(6): p. 685-690.

Kendal, A.R., P. Cooke, and R. Sharp, Arthroscopic Ankle Fusion for Avascular Necrosis of the Talus. Foot & Ankle International, 2015. 36(5): p. 591-597.

Kendal, A., Unintended consequences: might major surgery accelerate cancer? Reply. Bmj-British Medical Journal, 2014. 348.

Regateiro, F.S., et al., The induction of transplantation tissue tolerance requires Foxp3 expression. Allergy, 2013. 68: p. 181-181.

Kendal, A.R., et al., Mortality rates at 10 years after metal-on-metal hip resurfacing compared with total hip replacement in England: retrospective cohort analysis of hospital episode statistics. Bmj-British Medical Journal, 2013. 347.

Kendal, A., et al., MORTALITY FOLLOWING ELECTIVE TOTAL HIP REPLACEMENT AND HIP RESURFACING. Rheumatology, 2013. 52: p. 41-42.

Judge, A., et al., MORTALITY FOLLOWING ELECTIVE TOTAL HIP REPLACEMENT AND HIP RESURFACING. Osteoarthritis and Cartilage, 2013. 21: p. S162-S162.

Regateiro, F.S., et al., Foxp3 Expression Is Required for the Induction of Therapeutic Tissue Tolerance. Journal of Immunology, 2012. 189(8): p. 3947-3956.

Waldmann, H., et al., Metabolic aspects underlying immune regulation. Immunology, 2011. 135: p. 4-4.

Singh, A., et al., Patient Expectation and Satisfaction After Macular Hole Surgery. Optometry and Vision Science, 2011. 88(2): p. 312-316.

Kendal, A.R., et al., Sustained suppression by Foxp3<SUP>+</SUP> regulatory T cells is vital for infectious transplantation tolerance. Journal of Experimental Medicine, 2011. 208(10): p. 2043-2053.

Kendal, A.R. and H. Waldmann, Infectious tolerance: therapeutic potential. Current Opinion in Immunology, 2010. 22(5): p. 560-565.