The annual MCR poster competition brought some excellent entries from Trinity’s science graduates.
The judges were Professor Chris Butler, Dr Dorit Hockman and Dr Sam Vinko, and they placed the poster by Lien Davidson in first place.
Lien is a DPhil student and Clarendon Scholar in the Nuffield Department of Obstetrics and Gynaecology, under the supervision of Dr Kevin Coward, and based at the Institute of Reproductive Sciences. Her project focuses on developing the use of infra-red laser technology as a research tool in the reproductive science and is in collaboration with Research Instruments Ltd. The judges commended her poster for its clarity and attractive way in which it presented a complex scientific investigation for a non-specialist audience.
The judges awarded second place to Sam Sharma, a Wellcome Trust Clinical Research Fellow at the Nuffield Department of Medicine. Sam’s poster presented The Pursuit of the ‘Ideal’ Submucosal Injection, a key strand of his research, which he outlines as follows:
Traditional surgical methods for treating serious digestive diseases, such as colorectal cancer, although widely employed across the Western world, carry with them significant risks. The endoluminal approach describes the method of treating pathology, such as polyps, by methods such as Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD). In addition, collective therapeutic approaches such as Combined Endoscopic and Laparoscopic Surgery (CELS) may be used to overcome the limitations and challenges of EMR and ESD, whilst still obviating intestinal resection. Through injecting agents into the submucosal intestinal layer, we may improve the margin of safety, but this field is highly underdeveloped with Saline Solution (SS) being the primary submucosal injection agent (SMIA) used worldwide. The purpose of this study was to investigate the ability of twelve established and novel SMIAs – including normal saline, hyaluronic acid and thermo-sensitive polymers (TSP) – as well as some combinations of those agents, to create a durable submucosal cushion.
Novel and combination SMIAs yielded significantly superior results to SS, particularly with regards to persistent mucosal elevation – the most important feature of an SMIA. This factor combined with the possibilities of novel therapeutic agent seeding and auto-dissection makes TSP one of the most likely, ideal SMIAs. Interestingly, SMIAs that displayed poor individual outcomes, exhibited superior results when used in combination – likely due to synergistic chemical effects.
Posted: 25 June 2015