Paul Fairchild
Fellow and Tutor in Medicine

Professor Fairchild is Co-Director of the Oxford Stem Cell Institute

Profile

After graduating in Biological Sciences at the University of Leicester, I studied for a DPhil in the Nuffield Department of Surgical Sciences in Oxford where I developed a long-term interest in immunology, focussing initially on the rejection of transplanted organs. On completing my doctorate, I moved to the Department of Pathology at Cambridge University, where I spent five years working on the aetiology of autoimmune disease, before returning to Oxford in 1995 where I am currently Associate Professor and Lecturer in Medicine at the Sir William Dunn School of Pathology. Over the past few years my interests have evolved to span the fields of immunology and stem cell biology and I had the privilege of establishing the Oxford Stem Cell Institute in 2008 with the help of numerous colleagues, which currently encompasses 43 laboratories across 17 Departments of the University.

Teaching

I currently teach immunology and stem cell biology at various levels of the medical curriculum, including the second year course in Principles of Pathology and the final-year courses in Infection and Immunity. I also lecture in immunology for the Biochemistry and Biomedical Sciences degree courses. At Trinity, my main responsibility is to give tutorials in all aspects of Pathology. I was recently awarded an Excellent Teacher Award for my undergraduate teaching by the University of Oxford, Medical Sciences Division . I teach advanced topics in immunology for the MSc in Integrated Immunology and on the commercial application of stem cells for the MSc in Experimental Therapeutics.  In addition, I lead an annual course for the Department of Continuing Education on stem cell biology entitled Stem Cells: A Pathway through the Maze which attracts external candidates from around the world ( https://www.conted.ox.ac.uk/C130-5).  I have a number of DPhil students within my laboratory and serve as Director of Graduate Studies for a programme of studentships hosted by the Oxford Stem Cell Institute.  

Research

I have numerous research interests which span the fields of immunology and stem cell biology including the mechanisms of immune privilege displayed by tissues differentiated from pluripotent stem cells, the induction of immunological tolerance to stem cell-derived tissues, and the application of dendritic cells differentiated from induced pluripotent stem cells to the treatment of disease states as distinct as the lysosomal storage diseases and cancer vaccination (pdf article in International Innovation).

Selected Publications

Books and Edited Volumes:

    • Fairchild PJ (Ed.) Immunological Tolerance: Methods and Protocols. (June 2007) Humana Press. Totowa, New Jersey. ISBN 978-1-58829-652-8
    • Fairchild PJ (Ed.) Current Opinion in Organ Transplantation. Vol 14(4) Editor of section devoted to Transplantation Tolerance.
    • Fairchild PJ (Ed.) The Immunological Barriers to Regenerative Medicine. (October 2012) Springer-Verlag New York, LLC. ISBN-13: 978-1-46145-479-3

Selected Research Papers:

  • Sachamitr P, Hackett S and Fairchild PJ (2014) Induced pluripotent stem cells: Challenges and opportunities for cancer immunotherapy.  Front Immunol  doi: 10.3389/fimmu.2014.00176
  • Sacchamitr P and Fairchild PJ (2012) Cross presentation of antigen by dendritic cells: mechanisms and implications for immunotherapy. Expert Rev Clin Immunol 8(6):547-555. doi:10.1586/ECI.12.45
  • Silk KM, Silk JD, Ichiryu N, Davies TJ, Carpenter L, Watt SM, Cerundolo V, Fairchild PJ (2011) Cross-presentation of tumor antigens by induced pluripotent stem cell-derived CD141+ dendritic cells. Gene Therapy 19(10):1035-1040
  • Davies TJ, Fairchild PJ (2012) Optimization of protocols for derivation of mouse embryonic stem cell lines from refractory strains, including the non-obese diabetic mouse. Stem Cells Develop 21:1688-1700 (Epub: Nov 2011 doi:10.1089/scd.2011.0427)
  • Leishman AJ, Silk KM and Fairchild PJ (2011) Pharmacological manipulation of dendritic cells in the pursuit of transplantation tolerance. Curr Opin Organ Transplant 16(4):372-378.
  • Carpenter L, Malladi R, Yang C-T, French A, Pilkington KJ, Richard J. Forsey RJ, Sloane-Stanley J, Silk K, Davies T, Fairchild P, Enver T, Watt SM. (2011) Human induced pluripotent stem cells are capable of B cell lymphopoiesis. Blood 117:4008-4011
  • Fairchild PJ (2010) The challenge of immunogenicity in the quest for induced pluripotency. Nat Rev Immunol. 10:868-875
  • Lui KO, Boyd AS, Cobbold SP, Waldmann H and Fairchild PJ (2010) A role for regulatory T cells in acceptance of embryonic stem cell-derived tissues transplanted across an MHC barrier. Stem Cells 28:1905-1914
  • Tseng S-Y, Nishimoto KP, Silk KS, Majumdar AS, Dawes GN, Waldmann H, Fairchild PJ, Lebkowski JS, Reddy A (2009) Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells. Regen Med 4(4):513-526
  • Silk KM, Fairchild PJ (2009) Harnessing dendritic cells for the induction of transplantation tolerance. Curr Opin Organ Transplantation 14:344-350
  • Robertson NJ, Brook F, Gardner RL, Cobbold SP, Waldmann H and Fairchild PJ (2007) Embryonic stem cell-derived tissues are immunogenic but their innate immune privilege promotes the induction of tolerance. Proc Natl Acad Sci USA 104:20920-20925.
  • Yates SF, Paterson AM, Nolan KF, Cobbold SP, Saunders NJ, Waldmann H and Fairchild PJ (2007) Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation. J Immunol 179(2):967-976
  • Graca L, Daley, S, Fairchild PJ, Cobbold SP, Waldmann H (2006) Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myeloablative conditioning. BMC Immunol 7:9
  • Fairchild PJ, Nolan KF, Cartland S and Waldmann H (2004) Embryonic stem cells and the challenge of transplantation tolerance. Trends Immunol 25:465-470
  • Graca L, Le Moine A, Lin C-Y, Fairchild PJ, Cobbold SP and Waldmann H (2004) Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+ T cells. Proc Natl Acad Sci USA 101:10122-10126
  • Chen T-C, Waldmann H, and Fairchild PJ (2004) Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen, Dby. J Clin Invest 113:1754-1762
  • Chen T-C, Cobbold SP, Fairchild PJ and Waldmann H (2004) Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen. J Immunol 172:5900-5907
  • Fairchild PJ, Nolan KF, Graca L, and Waldmann H (2003) Stable lines of genetically modified dendritic cells from embryonic stem cells. Transplantation 76:606-608
  • Tone M, Tone Y, Fairchild PJ, Wykes M and Waldmann H (2001) Regulation of CD40 function by its isoforms generated through alternative splicing. Proc Natl Acad Sci USA 98(4):1751-1756
  • Fairchild PJ, Nolan KF, and Waldmann H (2003) Probing dendritic cell function by guiding the differentiation of embryonic stem cells. Methods Enzymol 365:169-186
  • Fairchild PJ, Brook FA, Gardner RL, Graca L, Strong V, Tone Y, Tone M, Nolan KF and Waldmann H (2000) Directed differentiation of dendritic cells from mouse embryonic stem cells. Curr Biol  10(23):1515-1518
  • Brocke S, Gijbels K, Allegretta M, Ferber I, Piercy C, Blankenstein T, Martin R, Utz U, Karin N, Mitchell D, Veromaa T, Waisman A, Gaur A, Conlon P, Ling N, Fairchild PJ, Wraith DC, O’Garra A, Fathman CG and Steinman L (1996) Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379:343-346
  • Liu GY, Fairchild PJ, Smith RM, Prowle JR, Kioussis D and Wraith DC (1995) Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3:407-415