Linford Briant
Junior Research Fellow in Biomedical Sciences

Profile

Linford Briant is a Junior Research Fellow in Biomedical Sciences at Trinity. He graduated with his MSci from the University of Bristol in Mathematics, and stayed in Bristol to do an interdisciplinary PhD in Physiology and Engineering Mathematics with Tony Pickering and Alan Champneys. He moved to Oxford in 2015 with his wife Serena, and lives in Risinghurst, Headington.

Research

Linford’s PhD dissertation involved mathematically modelling the sympathetic nervous system to understand the pathophysiology of hypertension. Linford joined the Oxford Centre for Diabetes, Endocrinology and Metabolism in November 2015 to work on an islet physiology project with Professor Patrik Rorsman. He was awarded a Sir Henry Wellcome Postdoctoral Fellowship in May 2016, which he began in January 2017. The title of his 4 year research project is “Functional and computational analyses of the regulation of glucagon secretion in health and disease”. He will combine experimental techniques with computational approaches to understand alpha-cell physiology in health and disease, with the support of Professor Rorsman and Professor Blanca Rodriguez (Department of Computer Science).

Selected Publications

Briant, L. J. B., Zhang, Q., Vergari, E., Kellard, J. A., Rodriguez, B., Ashcroft, F. M. and Rorsman, P. (2017). Functional identification of islet cell types by electrophysiological fingerprinting. J. R. Soc. Interface, 2017 14

Briant, L. J. B., O’Callaghan, E. L., Champneys, A. R., and Paton, J. F. (2015). Respiratory modulated sympathetic activity: a putative mechanism for developing vascular resistance? J. Physiol. (Lond.), 593(24):5341-5360

Briant, L. J. B., Paton, J. F., Pickering, A. E., and Champneys, A. R. (2015). Modelling the vascular response to sympathetic postganglionic nerve activity. J. Theor. Biol., 371:102-116

Briant, L. J. B., Stalbovskiy, A. O., Nolan, M. F., Champneys, A. R., and Pickering, A. E. (2014). Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats. J. Neurophysiol., 112(11):2756-2778